Features
Tec-Control Chromatography tests the radiochemical purity of specific Tc-99m-labeled radiopharmaceuticals. The accompanying chart shows which strips and solvents are required to perform each individual test. Some solvents must be purchased separately (see Sigma-Aldrich chart) due to hazardous material shipping restrictions.
Detailed instruction manuals are packaged with each strip container, although our Radiopharmaceutical QC Procedure Manual (151-000) explains paper chromatography in greater detail.
TEC-CONTROL ALUMINUM BREAKTHRU KIT
Simple 3-step procedure
The Aluminum Breakthru Kit provides a rapid, easy and inexpensive way to test aqueous solutions, particularly pertechnetate generator eluate, for trace quantities of aluminum. Aluminum forms an intense red precipitate with the indicator paper, and the intensity of the color is directly proportional to the amount of aluminum in the solution. The USP allows a concentration of aluminum ion in an injection ?10 micrograms per milliliter (10 µg/ml) in technetium 99m eluate prepared from Molybdenum 99 formed as a result of uranium fission.
Simple Procedure:
- Place a drop of the eluate or solution to be tested on the indicator paper. The best procedure is to form a hanging drop using a 19-22G needle.
- Place a drop of the standard aluminum solution on the indicator paper. Use the same size drop.
- Compare the intensity of the red spot formed. If the eluate spot is less intense than the standard solution, the eluate contains less than 10µg/ml aluminum.
| 150-780 | Chromatography Kit, Tec-Control Aluminum Breakthru Kit includes: Aluminum standard, 5 ml, 10 ug/ml, 50 indicator strips and manual |
|---|---|
| 151-000 | Procedure Manual, Radiopharmaceutical QC |
References:
- Miniaturized Chromatographic Quality-Control Procedures for Tc-99m Radiopharmaceuticals;
- A. Michael Zimmer and Dan G. Pavel, Journal of Nuclear Medicine, Vol. 18/12, Dec. 1977, pg. 1230. Technical Parameters Associated with Miniaturized Chromatography Systems; Raimund A. Taukulis, A.
- Michael Zimmer, Dan G. Pavel and Bhupendra A. Patel, University of Illinois Medical Center, Chicago, Illinois, Journal of Nuclear Medicine Technology, Vol. 7/1.
This 90-page manual explains Paper Chromatography, a QC method for evaluating the radiochemical purity of currently used Tc-99m-labeled radiopharmaceuticals. Procedures are quick and easy to use, a simple quality control solution for any nuclear medicine department.
Specifications
Chromatography Strips
| 150-001 | Strips, RED, 50/pkg |
|---|---|
| 150-005 | Strips, BLACK, 50/pkg |
| 150-025 | Strips, YELLOW, 50/pkg |
| 150-122 | Strips, ORANGE, 50/pkg |
| 150-125 | Strips, LIGHT BLUE, 50/pkg |
| 150-130 | Strips, GOLD, 50/pkg |
| 150-771 | Strips, DARK GREEN, 50/pkg |
| 150-951 | Strips, LIME, 50/pkg |
| 150-952 | Strips, PEACH, 50/pkg |
| 150-971 | Strips, TEAL, 50/pkg |
| 150-991 | Strips, PINK, 50/pkg |
| 150-782 | Strips, ALUMINUM, 50/pkg |
Chromatography Solvents
| 150-160 | Solvent, 20% Sodium Chloride, 30 ml |
|---|---|
| 150-773 | Solvent, DTPA, 5 ml |
| 150-781 | Solvent, Aluminum Standard, 5 ml, 10 µg/ml |
Related Items:
| 150-960 | Developing Vials, 10 ml, 288/case (used for all Tec-Control testing) |
|---|---|
| 150-961 | Developing Vials, 5 ml, 144/case (used for Sestamibi & Tetrofosmin) |
| 066-533 | Forceps, Curved, Locking, 9.5” l (24.1 cm) |
| 066-535 | Forceps, Straight, Locking, 9.5” l (24.1 cm) |
| 066-536 | Forceps, Curved, Non-Locking, 13.5” l (34.3 cm) |
|
Tec-Control Solvent Vendor: 800-558-9160 / www.sigmaaldrich.com Note: Customers outside the US should visit Sigma-Aldrich web site to locate a regional office. |
|
| Solvent Description | Vendor Part # |
|---|---|
| Acetone HPLC Grade | 27072-5 |
| Ethyl Acetate 99.5% ACS Reagent | 31990-2 |
| Chloroform 99.8% ACS Reagent | 31998-8 |
| Tetrahydrofuran 99+% ACS Reagent | 36058-9 |
Options
| RADIOPHARMACEUTICAL | SOLVENT REQUIRED* | STRIPS REQUIRED |
|---|---|---|
| Aluminum Breakthru | 150-781 | 150-782 |
| Bicisate (Neurolite™) | Ethyl Acetate 99.% | 150-130 |
| Diphosphonate | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| Disofenin (Hepatolite™) | 150-160, Distilled H2O | 150-122 & 150-125 |
| DMSA | Acetone (HPLC Grade), | 150-025 |
| DTPA | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| Exametazine (Ceretec™) | Ethyl Acetate 99.% | 150-130 |
| Glucoheptonate | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| HDP | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| MAA | Acetone (HPLC Grade), | 150-001 |
| MAG3 (Mertiatide™) | Acetone, (HPLC Grade), Chloroform 99.8% Tetrahydrofuran 99+% |
150-951 & 150-952 |
| MDP | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| Mebrofenin (Cholotec™) | 150-160, Distilled H2O | 150-122 & 150-125 |
| Pyrophosphate | Acetone (HPLC Grade), Distilled H2O | 150-001 & 150-005 |
| Sestamibi (Cardiolite™ and Miraluma™ | Ethyl Acetate 99.% | 150-991 |
| Sulphur Colloid | Acetone (HPLC Grade) | 150-001 |
| Tc-99m (reduced) | Acetone (HPLC Grade), | 150-001 |
| Tc-99m Monocolonal Antibodies | 0.9% Saline | 150-771 |
| Tetrofosmin (Myoview™) | Ethyl Acetate 99.% | 150-971 |
| In-111, Octreotide (Octreoscan™) | 150-773 & 0.9% Saline | 150-771 ** |
| In-11 Monocolonal Antibodies | 150-773 & 0.9% Saline | 150-771 ** |
| In-111/Y-90 Zevalin™ | 150-773 & 0.9% Saline | 150-771 |
| I-131 Monoclonal Antibodies And Neutrospec™ |
0.9% Saline | 150-771 |
* See Sigma-Aldrich product matrix for solvents.
** Note: A Well Plate is suggested to perform QC on these radiopharmacuticals
Contact Fisher Scientific Corp. 800-766-7000 / www.fishersci.com / Item #14-245-71
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